| 品系背景 | 基因名稱 | 基因ID | 應(yīng)用說明 |
| C57BL/6 | 41BB | ||
| C57BL/6 | CTLA4 | 12477 | Mice homozygous for a knock-out allele exhibit lethality at 3 to 4 weeks of age, decreased T cell numbers, abnormal T cell physiology, inflammation in mutliple organs, abnormal thymus morphology, and lymph node hypoplasia. |
| SD 大鼠 | CYP1A2 | 13077 | Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment. |
| SD 大鼠 | CYP2E1 | 13106 | Mice homozygous for a null allele exhibit altered responses to xenobiotics including decreased urethane-induced tumors and allylnitrile- or acetamenophen-associated mortality but increased allylnitrile-induced vestibular function loss. |
| C57BL/6 | hECM1 | 1893 | Mice homozygous for a knock-out allele exhibit auto-inflammatory disease and do not survive beyond 6 to 8 weeks of age. |
| C57BL/6 | hPear1 | 375033 | Mice homozygous for a knock-out allele show no apparent defects in hemostasis or thrombus formation. Although in vitro dextran sulfate-induced platelet aggregation is impaired, platelet aggregation initiated with physiological agonists is normal. |
| C57BL/6 | Mek1 | 26395 | Homozygous inactivation of this gene leads to reduced embryo size and midgestational lethality due to impaired development and hypovascularization of the placenta with decreased labyrinth cell proliferation and enhanced cell apoptosis. Mutant MEFs fail to exhibit fibronectin-induced migration. |
| C57BL/6 | nedd8 | 18002 | |
| C57BL/6 | Pah | 18478 | Homozygotes for ENU-induced mutations of this gene have altered serum and urine phenylalanine levels and may display reduced body size, microcephaly, microphthalmia, decreased litter size, hypopigmentation, impaired balance/swimming, cognitive deficits, and environmentally-induced seizures. |
| C57BL/6 | PD1 | 18566 | Mice homozygous for disruptions in this gene display abnormalities in leukopoiesis and the immune system which vary considerably depending on the genetic background. |
| C57BL/6 | PPM1K | 243382 | Mice homozygous for a null allele exhibit defective amino acid metabolism, increased oxidative stress, and increased mortality when subjected to a high-protein diet while in utero and during postnatal development. |
| C57BL/6 | Rab31 | 106572 | |
| C57BL/6 | Rosa26-CAG-SCFV+FC | ||
| C57BL/6 | SLC26A4 | 23985 | Homozygous null mutants are completely deaf with vestibular dysfunction. Mutants show endolymphatic dilatation, degeneration of sensory cells and malformations of otoconia and otoconial membranes. They display unsteady gait and circling and head bobbing. |
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